Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease. |
体外活性 | Incubation with Oxitropium bromide of the untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro; but, it induces both types of muscle to be fatigue resistant. Oxitropium bromide is a muscarinic antagonist that blocks musucarinic acetylcholine receptors (mAChR) [1]. |
体内活性 | Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4, or antigen is prevented by Oxitropium bromide Oxitropium bromide. Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo. Inhalation of the anticholinergic agent Oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine [1][2][3]. |
分子量 | 412.32 |
分子式 | C19H26BrNO4 |
CAS No. | 30286-75-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Oxitropium Bromide 30286-75-0 Neuroscience AChR Inhibitor inhibitor inhibit